Bi-Est topical cream jar

Actual vial appearance, contents, and dosage may vary based on your prescription.

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Women's Health

Performance Protocol

Bi-Estrogen (Bi-Est) Cream

Feel More Like Yourself.

A provider-guided approach to menopause care using a compounded estradiol and estriol cream, with treatment tailored to your symptoms, health history, and individual needs.

★ ★ ★ ★ ★ Provider Guided
$109.67 /month ~$3.66/day

Billed $329 for one complete 90-day protocol cycle. No automatic renewal.

CHOOSE YOUR PROTOCOL LENGTH
3 Months BEST VALUE 90-day protocol
90-day option offers a lower monthly rate.

How Your Protocol Works

No Subscription Required No Subscription
Required
Medical Consultation Included Medical Consultation
Included
Licensed Medical Oversight Licensed Medical
Oversight

Why This Protocol

Your Competitive Edge

COMMAND

Understand Your Symptoms

Explore how changing estrogen levels may contribute to hot flashes, night sweats, and disruptions to everyday comfort.

ELEVATE

Personalize Your Care

Work with a licensed provider to determine whether hormone therapy is appropriate and which formulation best meets your needs.

TRANSFORM

Prioritize Everyday Comfort

Focus your care on bothersome symptoms, with regular review of your response and treatment goals.

Why This Protocol

Your next chapter deserves care that understands you.

Changes during perimenopause and menopause can affect your comfort, sleep, and daily routine. Bi-Estrogen Cream combines estradiol and estriol in a prescription compounded formulation that a provider may consider when an FDA-approved option does not meet an individual patient’s medical needs.

Your provider will review your symptoms, medical history, current medications, and treatment preferences before recommending care. The estrogen ratio, strength, application instructions, and any additional hormone therapy are determined by your prescription.

The goal is thoughtful symptom management with ongoing medical oversight. Compounded Bi-Estrogen Cream is not FDA-approved, and evidence for its safety and effectiveness is limited. Your provider will discuss FDA-approved alternatives and the potential benefits and risks of your treatment options.

Is This Protocol Right For You?

Provider-guided menopause care

Bothersome hot flashes

Night sweats affecting comfort

Sleep disrupted by nighttime symptoms

Individualized hormone-therapy evaluation

Preference for a cream formulation

Best Uses For Bi-Estrogen (Bi-Est) Cream

Potential Benefits

01

May Help Manage Hot Flashes

Estrogen therapy can relieve menopausal hot flashes. Your response to a compounded Bi-Est formulation may vary.

02

May Help Reduce Night Sweats

When clinically appropriate, estrogen therapy may help address night sweats associated with menopause.

03

May Support More Restful Nights

Relief of nighttime hot flashes and sweating may help reduce related sleep disruption. This is not a treatment for all causes of insomnia.

04

May Improve Everyday Comfort

Managing bothersome menopause symptoms may help make everyday activities more comfortable.

05

Offers a Cream Administration Option

Provides a prescription cream format for individuals whose provider determines it is appropriate.

06

Supports Individualized Care

Allows a provider to consider a compounded formulation for a specific medical need, with ongoing review of symptoms and treatment response.

How It Works

1 Assessment

Assessment

Complete a quick online assessment to share your health history and goals.

2 Provider Review

Provider Review

A licensed provider reviews your information and determines if this protocol is right for you.

3 Medication Shipped

Medication Shipped

If prescribed, your medication is shipped discreetly to your door.

What's Included

Provider Evaluation
Prescription if Appropriate
Medication
Ongoing Provider Support
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Progress Tracking & Guidance

What To Expect

A Clear, Medically Guided Process

01

Consultation

Meet with a licensed provider to review your symptoms, menstrual and menopause history, current medications, and personal and family medical history. Your provider will discuss treatment options and whether hormone therapy is appropriate.

02

Personalized Treatment Plan

If appropriate, your provider will select a treatment plan based on your symptoms and medical needs. You will receive specific instructions for your prescribed formulation, including application, dose, and whether additional medication is needed.

03

Ongoing Support

Follow-ups allow your provider to review symptom changes, side effects, and whether treatment should continue or be adjusted. Report new or unexpected vaginal bleeding promptly.

Frequently Asked Questions

Everything to know before you start.

What is Bi-Estrogen Cream? +
Bi-Est, short for bi-estrogen, generally refers to a compounded combination of estradiol and estriol. The ratio and concentration depend on your prescription. Your provider and pharmacy will confirm the ingredients in your formulation.
What symptoms is this protocol intended to address? +
Your provider may consider estrogen therapy for bothersome symptoms of perimenopause or menopause, such as hot flashes and night sweats. The benefits of compounded Bi-Est Cream have not been established to the same standard as FDA-approved hormone therapies.
Does this cream contain progesterone? +
Bi-Est refers to the two estrogen ingredients; it does not indicate that progesterone is included. If you have a uterus and receive systemic estrogen, a progestogen is generally needed to help protect the uterine lining. Your provider will determine the appropriate regimen.
How do I apply the cream? +
Follow the instructions from your provider and dispensing pharmacy. The application site, amount, and frequency depend on the prescribed formulation. Do not assume a skin cream is intended for vaginal use. Ask your pharmacy about drying time, handwashing, and avoiding transfer to others.
How quickly will I notice changes? +
Response varies with the formulation, dose, symptoms, and individual health profile. Your provider will explain when to reassess your symptoms and whether any changes to treatment are appropriate.
Is compounded Bi-Estrogen Cream FDA-approved? +
No. Compounded medications are not FDA-approved, and the FDA does not review them for safety, effectiveness, or quality before marketing. FDA-approved hormone therapies are generally preferred when they meet a patient’s needs. Your provider will explain why a compounded option may be considered.
What if I experience side effects? +
Possible side effects include breast tenderness, spotting or bleeding, headache, and application-site irritation. Estrogen therapy can also carry serious risks, including blood clots and stroke, depending on individual factors and treatment. Your provider will review these risks and whether treatment is appropriate. Report unexpected vaginal bleeding promptly.
Is hormone therapy right for everyone? +
No. Your provider will review factors such as unexplained vaginal bleeding, a history of hormone-sensitive cancer, blood clots, stroke, liver disease, and possible pregnancy, along with your overall medical history. These factors may affect whether hormone therapy is appropriate.
How long will I stay on treatment? +
Duration depends on your symptoms, response, preferences, and medical history. Your provider will periodically review the benefits and risks and determine whether to continue, adjust, or stop treatment.
Will this help with weight loss or reverse aging? +
This protocol is focused on menopause symptom management. It is not a weight-loss or anti-aging treatment. Your provider can help you address those goals separately.

Ready to Feel More Like Yourself?

Every Level IX protocol begins with a comprehensive provider evaluation to explore your symptoms, health history, and treatment goals. Take the next step toward care tailored to your stage of life.

Start Your Assessment →
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